Dietary calcium may prevent the spread of breast cancer to bone

A strong skeleton is less likely to be penetrated by metastasizing cancer cells, so a fortified glass of milk might be the way to block cancer’s spread, according to researchers at the ANZAC Research Institute in Concord, Australia. Using a mouse model of breast cancer metastasis, the researchers found that a calcium deficiency may increase the tendency of advanced breast cancer to target bone. Dietary calcium, they reason, might help prevent the spread of breast cancer to bone and serve as an adjuvant treatment during therapy.Their findings are presented in the Oct. 1 issue of Cancer Research, a journal of the American Association for Cancer Research.

According to the researchers, about 70 percent of patients who develop advanced breast cancer will have secondary tumors in the bone. The spread of cancer to bones leads to cellular processes that physically break down existing bone, leading to further pain and illness. In fact, the breakdown of bone and subsequent bone re-growth forms what senior author Colin R. Dunstan, Ph.D., terms a “vicious cycle” that turns bone into an environment conducive to cancer growth.

To better understand the role of bone turnover in the spread of cancer, Dunstan and his team compared the effects of a low- and high-calcium diet in mice. They found that dietary calcium deficiency – independent of the chemical factors that control turnover – was related to a significantly higher increase in cancer cell proliferation and the total proportion of bone that had been penetrated.

“These results could have implications for patients with breast cancer bone metastases or who are at high risk for developing metastatic disease,” Dunstan said. “Many older women in our community are known to be calcium deficient due to low calcium dietary intake or due to vitamin D deficiency. These women could be at increased risk for the devastating effects of bone metastases.”

According to Dunstan, his results call for further, directed clinical trials “to investigate how calcium and vitamin D status influence progression to metastatic disease, and to determine if corrections of calcium and vitamin D deficiencies are important in breast cancer patients.”

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Article adapted by MD Only Weblog from original press release.
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Contact: Greg Lester
American Association for Cancer Research

The ANZAC Research Institute study was funded by the National Health and Medical Research Council of Australia and the New South Wales Government.

The mission of the American Association for Cancer Research is to prevent and cure cancer. Founded in 1907, AACR is the world’s oldest and largest professional organization dedicated to advancing cancer research. The membership includes nearly 26,000 basic, translational, and clinical researchers; health care professionals; and cancer survivors and advocates in the United States and more than 70 other countries.

AACR marshals the full spectrum of expertise from the cancer community to accelerate progress in the prevention, diagnosis and treatment of cancer through high-quality scientific and educational programs. It funds innovative, meritorious research grants. The AACR Annual Meeting attracts more than 17,000 participants who share the latest discoveries and developments in the field. Special Conferences throughout the year present novel data across a wide variety of topics in cancer research, treatment, and patient care.

AACR publishes five major peer-reviewed journals: Cancer Research; Clinical Cancer Research; Molecular Cancer Therapeutics; Molecular Cancer Research; and Cancer Epidemiology, Biomarkers & Prevention. Its most recent publication, CR, is a magazine for cancer survivors, patient advocates, their families, physicians, and scientists. It provides a forum for sharing essential, evidence-based information and perspectives on progress in cancer research, survivorship, and advocacy.

Taking Painkillers, NSAID Increase the Risk for Heart Attack

Painkillers-new and old-increase the risk for heart attack

 Cardiovascular side effects aren’t limited to the use of the newer painkillers called COX-2 inhibitors-a category that includes Celebrex and the recently discontinued Vioxx and Bextra. Old standbys, like ibuprofen and aspirin, aren’t entirely blameless, reports the October 2006 issue of the Harvard Heart Letter. The cardiovascular risks associated with traditional NSAIDs are small, but worth being aware of.

Ibuprofen, aspirin, and COX-2s all belong to the class of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs). Most of them boost blood pressure and can counteract the effect of some blood-pressure drugs. They can also impair blood vessels’ ability to relax and may stimulate the growth of smooth muscle cells inside arteries. All these changes can contribute to the artery-clogging process known as atherosclerosis.

Researchers have determined that use of a COX-2 inhibitor increases the chances of having a heart attack. Vioxx, which was taken off the market because of possible heart complications, may lead to or worsen heart failure-but so can traditional NSAIDs. In general, cardiovascular side effects are most likely to happen in people with existing heart disease or those at high risk for it. 

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Article adapted by MD Only Weblog from original press release.
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Source: Harvard Health Publications
Contact: hhpmedia@hms.harvard.edu
Web site: http://www.health.harvard.edu

Diet rich in fatty acids could thwart diabetes onset

Omega-3 fatty acids have long been touted for their heart-healthy and brain-boosting benefits. Consider cod liver oil, fortified infant formula and enriched eggs.Now a study of nearly 1,800 children at risk for type 1 diabetes has found that increased consumption of dietary omega-3 fatty acids appears to reduce the risk of the body attacking its own insulin-producing cells, a precursor to this form of the disease, report researchers at the University of Colorado and the University of Florida.

The findings appear in the Sept. 26 issue of the Journal of the American Medical Association.

In the past few decades, there has been a dramatic rise in the incidence of type 1 diabetes, both in the United States and in Europe — a jump that coincides with changes in food manufacturing that have led to a decline in omega-3 fatty acids in the diet and an increase in the content of omega-6 fatty acids, said Dr. Michael Clare-Salzler, a professor and the Stetson chair in experimental pathology at the University of Florida College of Medicine.

“The foods we are eating now are qualitatively much different than those produced on a 1900s-era farm,” Clare-Salzler said. “When animals are commercially raised today, they are often fed grains rich in omega-6 fatty acids, fatty acids that can promote inflammation. In the old days, animals received a much more balanced intake of omega-3 and omega 6-fatty acids.”

The amount of omega-3 fatty acids found in food today has dropped 28-fold from 100 years ago, Clare-Salzler said. In contrast to the omega-6 variety, omega-3 fatty acids have potent anti-inflammatory effects.

“Animal studies have shown inflammation in the insulin-producing cells of the pancreas is an early event that leads to type 1 diabetes,” said Clare-Salzler, who also directs UF’s Center for Immunology and Transplantation. “From these studies in mice, it appears if you thwart inflammation you can prevent the disease from occurring. The human parallel in this study indicates that higher dietary intake of anti-inflammatory omega-3 fatty acids reduces the risk of developing an immune response to the insulin-producing cells.”

Scientists set out to study whether increased intake of omega-3 fatty acids would be associated with prevention of or delay in the emergence of autoantibodies in the blood that signal the immune system’s attack on insulin-producing cells. Children enrolled in the Denver-based Diabetes Autoimmunity Study in the Young, or DAISY, were all at increased risk for type 1 diabetes and were evaluated until they were, on average, 6 years old.

Their parents were asked annually to report what they ate, including how often they consumed canned tuna, dark-meat fish such as salmon, other fish, shrimp, lobster and scallops, and also what kind of fat was used in cooking. Blood samples also were taken to test study participants for the presence of autoantibodies, and Nancy J. Szabo, director of the Analytical Toxicology Core Laboratory at UF’s College of Veterinary Medicine, evaluated the fatty acid composition of red blood cell membranes isolated from blood samples taken from a subset of 244 children.

“Kids who had higher intakes of omega-3 fatty acids had a significant reduction in the risk of development of autoantibodies,” Clare-Salzler said, adding that the risk of developing the autoantibodies also went down as the concentration of omega-3 fatty acids rose in the red blood cells.

All fatty acids help bolster the structure and function of cell membranes, but omega-3 fatty acids strongly support the production of anti-inflammatory molecules than can quell an immune attack on insulin-producing cells, Clare-Salzler said.

The study’s lead author was Jill M. Norris, a professor of preventive medicine and biometrics at the University of Colorado at Denver’s School of Medicine. Funding came from the National Institutes of Health and the University of Colorado’s Diabetes Endocrine Research Center.

UF and University of Colorado researchers are continuing to explore links between diabetes and diet. Clare-Salzler and Peter Chase from the University of Colorado’s Barbara Davis Center for Childhood Diabetes are leading a National Institutes of Health-funded multicenter pilot trial, the Nutritional Intervention to Prevent Type 1 Diabetes, or NIP, to examine whether babies who receive dietary supplementation with the omega-3 fatty acid docosohexaenoic acid, or DHA, show fewer signs of inflammation. An expanded version of the trial will then determine whether DHA protects infants and children from the development of autoantibodies that lead to diabetes in comparison with babies who receive standard formula or diets with a much lower level of the omega-3 fatty acid.

If the trial confirms the hypothesis that dietary supplementation with DHA in infancy blocks early inflammatory events key to diabetes development, then, the authors write in JAMA, “dietary supplementation with omega-3 fatty acids could become a mainstay for early intervention to safely prevent the development of type 1 diabetes.”

“The compounds that are made from the omega-3s are natural, the body’s own protective mechanisms for overt inflammation,” said Dr. Charles Serhan, director of the Center for Experimental Therapeutics and Reperfusion Injury at Harvard Medical School. “What these results say is that you may now be able to add back through the diet these essential omega-3 fatty acids, and then they will be utilized by the body to generate its own set of protective molecules that help to instruct the immune cells in the local environment not to attack the insulin-producing islets cells in the pancreas … these are very powerful and potentially very important results.”

Source: Melanie Fridl Ross, ufcardiac@aol.com 

University of Florida Health Science Center
1600 S.W. Archer Rd., Rm. C3-025
Gainesville, FL 32610
United States
http://www.health.ufl.edu

Natural compound in chocolate boost memory…

May help protect against cognitive decline in aging

A natural compound found in blueberries, tea, grapes, and cocoa enhances memory in mice, according to newly published research. This effect increased further when mice also exercised regularly.

“This finding is an important advance because it identifies a single natural chemical with memory-enhancing effects, suggesting that it may be possible to optimize brain function by combining exercise and dietary supplementation,” says Mark Mattson, PhD, at the National Institute on Aging.

The compound, epicatechin, is one of a group of chemicals known as flavonols and has been shown previously to improve cardiovascular function in people and increase blood flow in the brain. Flavonols are found in some chocolate. Henriette van Praag, PhD, of the Salk Institute, and colleagues there and at Mars, Inc., showed that the combination of exercise and a diet with epicatechin also promoted structural and functional changes in the dentate gyrus, a part of the brain involved in the formation of learning and memory. The findings, published in the May 30 issue of The Journal of Neuroscience, suggest that a diet rich in flavonols may help reduce the incidence or severity of neurodegenerative disease or cognitive disorders related to aging.

Van Praag and her team compared mice fed a typical diet with those fed a diet supplemented with epicatechin. Half the mice in each group were allowed to run on a wheel for two hours each day. After a month, the mice were trained to find a platform hidden in a pool of water. Those that both exercised and ate the epicatechin diet remembered the location of the platform longer than the other mice.

When studying their brains, van Praag and her colleagues found that these mice had greater blood vessel growth in the dentate gyrus and had developed more mature nerve cells, suggesting an enhanced ability of the cells to communicate. Further analysis showed that the epicatechin and exercise combination had a beneficial effect on the expression of genes important for learning and memory, and decreased the activity of genes playing a role in inflammation and neurodegeneration.

The researchers found that sedentary mice fed epicatechin showed enhanced memory, blood vessel growth, and gene activity, but these benefits were even more evident in mice that also exercised.

“A logical next step will be to study the effects of epicatechin on memory and brain blood flow in aged animals,” says van Praag, “and then humans, combined with mild exercise.”

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Article adapted by MD Only Weblog from original press release.
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The work was a supported by a grant from the US Defense Department’s Defense Advanced Research Projects Agency. Mars, which markets a flavonol-rich line of chocolate, supplied the epicatechin.

The Journal of Neuroscience is published by the Society for Neuroscience, an organization of more than 36,500 basic scientists and clinicians who study the brain and nervous system. Van Praag can be reached at vanpraag@salk.edu.

Contact: Sara Harris
Society for Neuroscience

Red meat linked to breast cancer

Eating red meat increases a woman’s chance of developing breast cancer, according to new research from the University of Leeds.

The findings are most striking for post-menopausal women – those with the highest intake of red meat, the equivalent to one portion a day (more than 57 grams) – run a 56 per cent greater risk of breast cancer than those who eat none. Women who eat the most processed meat, such as bacon, sausages, ham or pies, run a 64 per cent greater risk of breast cancer than those who eat none.

Researchers at the University’s Centre for Epidemiology and Biostatistics have been tracking the eating habits and health of more than 35,000 women for the past seven years, and their latest findings are published in the British Journal of Cancer. Earlier findings, widely reported in January, showed that pre-menopausal women who have the greatest intake of fibre have cut their risk of breast cancer in half.

Read full text of the report from the British Journal of Cancer

For more information:

LEEDS UNIVERSITY
Leeds
LS2 9JT
http://www.leeds.ac.uk

Eating red meat may increase rheumatoid arthritis risk

Consuming high levels of red meat study says is an independent risk factor in the development of inflammatory arthritis

A chronic inflammatory disease of the immune system, rheumatoid arthritis (RA) has been linked to a combination of genetic and environmental factors. Aspects of lifestyle may explain as much as 40 percent of the risk. Cigarette smoking has consistently been found to play a role in RA’s development. The role of nutritional factors is less certain. Studies have suggested the protective benefits of eating fish, the dangers of drinking coffee, and a reduction in disease risk for women who enjoy alcohol in moderation. Such associations, however, are still wide open to debate and further research.Recently, a team of British researchers found that a diet lacking in fruit, especially varieties high in vitamin C, increases the risk of inflammatory arthritis, a common early sign of RA, as much as three-fold. Building on this compelling finding, they set out to investigate the association of other dietary habits with the onset of RA. Their results, published in the December 2004 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis), indicate a high level of red meat consumption as an independent risk factor for inflammatory arthritis.

Led by Professors Alan Silman and Deborah Symmons at the University of Manchester, the team drew its subjects from a large, established research sample–over 25,000 men and women between the ages of 45 and 75 enrolled in the European Prospective Investigation of Cancer in Norfolk, England. Within this population, 88 new patients with inflammatory arthritis, affecting at least two major joints, were identified.

Nearly 40 percent of these patients satisfied the American College of Rheumatology criteria for RA at baseline. The patients were then matched, for age, sex, and body mass index, with 176 controls. At the study’s onset, each participant completed a detailed 7-day food diary, with advance instruction on measuring food portions to help them be as specific as possible in recording their intake. Each participant also supplied information on his or her past and present status as a smoker.

Patients were more likely to have been former smokers; only 35 percent of the patients had never smoked compared with 85 percent of the controls. In terms of dietary factors, patients and controls were similar in most areas, including intake of total calories, fat grams, and vitamin D, as well as coffee, tea, and alcohol consumption. Patients had a lower intake of vitamin C, although the association of this factor with disease risk was not as strong as it was in the team’s previous study. The most striking difference between the two groups was directly related to red meat consumption. After adjusting for smoking and other possible dietary confounders, patients with the highest level of red meat consumption had a two-fold risk for the development of RA. Patients who consumed high levels of red meat combined with other meat products showed similar high risk levels. Interestingly, a higher level of protein intake from all dietary sources was also associated with an increased disease risk, while higher levels of dietary fats, including saturated fat, did not have an impact.

Routinely eating burgers and steak, however, may only influence people with a predisposition for RA. “It may be that the high collagen content of meat leads to collagen sensitization and consequent production of anticollagen antibodies, most likely in a subgroup of susceptible individuals,” the authors note. “Meat consumption may be linked to either additives or even infectious agents, but, again, there is no evidence as to what might be important in relation to RA.”

“A high level of red meat consumption may represent a novel risk factor for inflammatory arthritis or may act as a marker for a group of persons with an increased risk from other lifestyle causes,” Dr. Pattison and colleagues conclude. “It is unclear whether the association is a causative one.”

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Article adapted by MD Only Weblog from original press release.
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Article: “Dietary Risk Factors for the Development of Inflammatory Polyarthritis: Evidence for a Role of High Level of Red Meat Consumption,” Dorothy J. Pattison, Deborah P.M. Symmons, Mark Lunt, Ailsa Welch, Robert Luben, Sheila A. Bingham, Kay-Tee Khaw, Nicholas E. Day, and Alan J. Silman, Arthritis & Rheumatism, December 2004; 50:12; pp. 3804-3812.

Contact: Amy Molnar
amolnar@wiley.com
John Wiley & Sons, Inc.

Cinnamon and Cloves Double Team Diabetes and Cardiovascular Disease

Cinnamon and cloves shown in studies to improve insulin function, lower risk factors for diabetes, and cardiovascular disease.

Two studies provide new evidence for the beneficial effects (and biochemical actions) of cinnamon as an anti-inflammatory agent and support earlier findings of its power as an anti-oxidant agent and an agent able to lower cholesterol, triglycerides, and glucose, and improve how well insulin functions.In a related study, extracts of cloves also were found to improve the function of insulin and to lower glucose, total cholesterol, LDL and triglycerides in people with type 2 diabetes. Earlier studies had shown these positive effects in laboratory studies; one study presented at Experimental Biology provides the first evidence of these beneficial effects in humans taking the equivalent of one to two cloves per day.

Earlier studies in the laboratory of one of the co-authors of all these papers, Dr. Richard A. Anderson, Beltsville Human Nutrition Research Center, United States Department of Agriculture, had shown that the equivalent of a quarter to half a teaspoon of cinnamon given to humans twice a day decreased risk factors for diabetes and cardiovascular disease, including glucose, cholesterol and triglycerides, by 10 to 30 percent. These new studies showing cinnamon’s ability to block inflammation extend our understanding of the potential for the spice, says Dr. Anderson. As an anti-inflammatory agent, cinnamon may be useful in preventing or mitigating arthritis as well as cardiovascular disease. And as scientists increasingly understand the relationship between inflammation and insulin function in Alzheimer’s (causing some to refer to the neurodegenerative disease as “type 3 diabetes”), cinnamon’s ability to block inflammation and enhance insulin function may make it useful in combating that disease as well.

The cinnamon and clove studies were presented at Experimental Biology in San Francisco as part of the scientific program of the American Society for Nutrition, Inc. The three studies are:

• Dr. Heping Cao of the Beltsville Human Nutrition Research Center and colleagues, including Dr. Anderson, investigated the biochemical basis for the insulin-like effects of cinnamon. Results showed that cinnamon, like insulin, increases the amount of three critically important proteins involved in the body’s insulin signaling, glucose transport, and inflammatory response. Dr. Cao says the study provides new biochemical evidence for the beneficial effects of cinnamon in potentiating insulin action and suggests anti-inflammatory properties for the antioxidants in cinnamon. Other researchers involved in the study are Dr. Marilyn M. Polansky of the USDA-ARS Beltsville (Maryland) Human Nutrition Research Center, and Dr. Perry J. Blackshear of the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
• Dr. Stephanie Mae Lampke, University of California, Santa Barbara (UCSB), and colleagues, used fractionation and electrospray mass spectrometry to identify the chemical structure of active ingredients in cinnamon. She worked with UCSB’s James Pavolich and Donald Graves. This study provides information on how cinnamon works. Working with Dr. Lampe, Dr. Anderson, and Dr. Polansky (also involved in the paper above) were members of the USDA BHNRC. Research was supported in part by a grant from Cottage Hospital, Santa Barbara, to Dr. Graves.
• Dr. Alam Khan, Agricultural University, Peshawar, Pakistan, a former postdoctoral student and Fulbright Fellow in the Anderson laboratory, reports the first study of the effect of cloves on insulin function in humans. Thirty-six people with type 2 diabetes were divided into four groups, which then took capsules with either 0, 1, 2, or 3 grams of cloves for 30 days. There were no significance differences in responses among the three levels of cloves used – but there were markedly significant differences between those who took cloves and those who did not. At the end of the 30 days, individuals with diabetes who had been taking some level of clove supplementation showed a decrease in serum glucose from an average 225 to 150 mg/dL, triglycerides from an average 235 to 203 mg/dL, a decrease in serum total cholesterol from 273 to 239 mg/dL, and a decrease in LDL from 175 to 145 mg/dL. The individuals with diabetes who had not been taking clove capsules showed no differences. Serum HDL was not affected by consumption of cloves.

The people with diabetes who had been in the experimental group then were taken off clove supplementation and, after 10 days, their glucose, triglycerides, total cholesterol and LDL measured. Although these had begun to rise somewhat, all remained significantly lower than at the beginning of the study. Dr. Khan says the finding that intake of 1 to 3 grams of cloves per day lowered risk factors of diabetes without changing HDL concentration suggest strongly that cloves are beneficial for people with type 2 diabetes. Co-authors of the study in addition to Dr. Khan and Dr. Anderson are Dr. Syed Saceed Qadir, Agricultural University, Peshawar, Pakistan, and Dr. Khan Nawaz Khattak, HMC, Hayatabad, Peshawar, Pakistan. The research was supported by the Higher Education Commission of Pakistan.

The effect of cinnamon is a major research interest in Dr. Anderson’s laboratory, where human studies are now taking place looking at how this ingredient can improve insulin functioning in women with polycystic ovary syndrome (a disease of insulin sensitivity in which perturbed hormone levels cause difficulty in getting pregnant, among other problems), people with type 2 diabetes and the prediabetic metabolic syndrome; and people who are very obese (because Dr. Anderson believes that improving insulin function will lead to improvements in weight and lean body mass).

A post doctoral fellow in the Anderson laboratory also is beginning to investigate whether improving insulin functioning will decrease the chance of developing Alzheimer’s disease.

Two final bits of advice from Dr. Anderson: First, eating great quantities of cinnamon straight from the can is not a good idea. Table cinnamon is not water soluble, meaning it can build up in the body with unknown consequences. Second, the powered cinnamon has another limitation. Dr. Anderson’s personal 60-point decline in total cholesterol occurred only after he switched from sprinkling cinnamon on his breakfast cereal to taking it in a capsule. Saliva contains a chemical harmful to cinnamon.

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Article adapted by MD Only Weblog from original press release.
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Contact: Sarah Goodwin
ebpress@bellsouth.net
Federation of American Societies for Experimental Biology

Today’s Diseases Linked To Fetal and Infant Toxcity

Researchers find that later-life diseases resulting from fetal and infant toxicity have common immune pattern

A Cornell researcher and his wife have conducted the first comprehensive review of later-life diseases that develop in people who were exposed to environmental toxins or drugs either in the womb or as infants. They have found that most of the diseases have two things in common: They involve an imbalanced immune system and exaggerated inflammatory reactions (at the cellular level).

In an invited, peer-reviewed article on developmental immunotoxicity (DIT), published in a recent issue of Current Medicinal Chemistry, Rodney Dietert, professor of immunotoxicology at Cornell’s College of Veterinary Medicine, and Janice Dietert of Performance Plus Consulting in Lansing, N.Y., found that almost all the chronic diseases that are associated with DIT share the same type of immunological damage.

The diseases linked to DIT include asthma, allergy, suppressed responses to vaccines, increased susceptibility to infections, childhood neurobehavioral conditions, autoimmunity, cancer, cerebral palsy, atherosclerosis, hypertension and male sterility.

Toxins that are known to cause developmental immune problems in fetuses and neonates, according to the Dieterts, include herbicides, pesticides, alcohol, heavy metals, maternal smoking, antibiotics, diesel exhaust, drugs of abuse and PCBs.

Antidotes to DIT, the researchers note, could come from a variety of sources, including herbal and fungal chemicals — from mushrooms to clover — which appear to have promise.

Two immune processes — T helper (Th) cell balances and dendritic cell maturation — are both compromised in ways that disrupt the regulation of inflammatory cell function, which leads to exaggerated inflammatory responses.

“Most therapeutic approaches have looked at specific disease outcomes from DIT, rather than focusing on the underlying immune dysfunction that creates the increased disease risk,” said Rodney Dietert, who also presented his findings March 28 at the annual Society of Toxicology meeting in Charlotte, N.C. “Instead, we looked at the common immune dysfunction that is related to a host of diseases.”

Knowing the most common immune dysfunction patterns from DIT allows researchers to consider more seriously those “medicinals with the capacity to restore inflammatory cell regulation, promote dendritic cell maturation and restore desirable Th balance that would be the most likely candidates to combat the problems resulting from DIT.”

Focusing on studies of herbal and fungal chemicals, the Dieterts scoured the literature and found that some of the chemicals appear to be particularly promising when taken at appropriate doses. These include: Astragalus; Echinacea (purple coneflower); sang-hwang shiitake, reishi, maitake and snake butter mushrooms, black seed, Asian ginseng, milk vetch root, wild yam, Sophoro root and Greek clover (all of these also go by various other names).

In their paper, the Dieterts also list a multitude of substances that have been found to have “an uncertain impact” on DIT as well as several found to exacerbate immune dysfunction (including marijuana).

“We hope that these findings of persistent immune dysfunction from gestational exposure will provide encouragement for additional research. Furthermore, that researchers will look at these categories of medicines that have the possibility of correcting inflammatory and immune balance problems resulting from DIT rather than focusing solely on individual disease symptoms,” Rodney Dietert said.

He noted that until recently toxin-testing guidelines predicted only risk in adults, but that the Environmental Protection Agency has announced it will issue new guidelines to take into account the increased immune sensitivity of fetuses and young children.

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Article adapted by MD Only Weblog from original press release.
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Contact: Sabina Lee
Cornell University News Service